Profhilo, Seventy Hyal 2000, and Polynucleotides - A Complete Guide
Skin boosters are minimally volumising intradermal injectables designed to improve skin quality, hydration, elasticity and microtexture rather than create structural volume. They work by providing hygroscopic material that attracts and holds water, and/or by stimulating local cellular pathways that increase collagen, elastin and dermal matrix repair.
The market includes HA-based products like Profhilo and Seventy Hyal 2000, and non-HA biologics such as polynucleotide formulations. Recent reviews classify skin boosters broadly by ingredient class and mechanism.
Thermally stabilised, non-chemically cross-linked HA. 64 mg total HA per 2 ml syringe (split high and low molecular weight), designed to spread and bioremodel. Protocol commonly 2 sessions, one month apart, with 5 injection points per side for the face.
High HA concentration with high molecular weight fraction (>2000 kDa), aimed at deeper hydration and longer-lasting water retention in the dermis. Protocols and injection patterns vary by manufacturer guidance.
Not HA – purified DNA fragments or polynucleotide chains derived from salmon or other sources. Act by activating tissue repair pathways, modulating inflammation, and supporting extracellular matrix remodelling. Includes brands like Rejuran, Plinest, and Plinest PN.
Provide water binding plus mechanical stimulation of dermal fibroblasts and indirect stimulation of collagen, depending on HA size and concentration. Thermally stabilised, non-crosslinked HA like Profhilo is formulated to diffuse and bio-remodel rather than act as a filler bolus.
Products like Seventy Hyal 2000 are intended to increase residence time and water retention, producing profound hydration and potentially longer effect on skin turgor.
Work through biochemical cell signalling, adenosine receptor pathways, and the salvage pathway that supports tissue repair and anti-inflammatory effects. May help scarring, pigmentation and elasticity in ways HA cannot. Evidence is promising, but study designs and product heterogeneity mean results vary.
Hyaluronic acid-based treatments (Profhilo and Seventy Hyal 2000) have excellent safety profiles with minimal risk of allergic reactions. Polynucleotide treatments are derived from salmon DNA, so please inform your practitioner if you have fish allergies. A patch test may be recommended.
Each product offers a different marketing proposition, allowing clinics to match patient needs: intense hydration (Seventy Hyal 2000), broad bioremodeling with simple protocol (Profhilo), or biologic regeneration and repair (polynucleotides). This variety supports treatment plans and follow-ups.
Contains pure hyaluronic acid in two molecular weights that work together to hydrate and stimulate your skin's natural collagen production. No added chemicals or cross-linking agents.
Features high-concentration hyaluronic acid with larger molecules designed to hold more water in your skin for longer-lasting hydration and plumping effects.
Contains purified DNA fragments (often from salmon) that work differently from hyaluronic acid by triggering your skin's natural repair processes. Important: Please inform your practitioner if you have fish allergies.
During your consultation, we'll discuss your skin concerns, medical history, and any allergies. Please mention if you're pregnant, breastfeeding, taking blood thinners, or have had recent skin treatments. For polynucleotide treatments, we'll specifically ask about fish allergies. A patch test may be recommended.
Your face will be cleansed, and a topical numbing cream may be applied for comfort. The treatment involves small injections placed strategically across the treatment area:
Most treatments take 30-45 minutes.
You may experience mild redness, slight swelling, or tenderness which typically resolves within 24-48 hours. For best results:
Microneedling, PRP, laser resurfacing and chemical peels pair well with boosters for combined skin quality plans.
You may experience temporary redness, mild swelling, tenderness, or light bruising at injection sites. These effects are normal and typically fade within a few days.
Always inform your practitioner about your complete medical history, current medications, and any allergies during your consultation to ensure skin boosters are safe and suitable for you.
Commonly reported improvements last 3–12 months depending on product, dosing and individual factors. Profhilo often shows skin quality improvement for around 6 months after a 2-session course. Maintenance recommended at 6–12 months. Seventy Hyal 2000, with higher HA load, is marketed for longer hydration though real world longevity varies.
Clinical studies report improvement in elasticity and wrinkles lasting from several months up to a year, with typical protocols involving an initial course then maintenance treatments. Heterogeneity of products and study designs makes precise prediction case dependent.
Skin boosters are about improving your skin's quality and health, not adding volume like traditional fillers. Results develop gradually over weeks to months as your skin naturally responds to the treatment.
Each skin booster serves a different purpose: Profhilo offers broad skin remodeling with a simple protocol, Seventy Hyal 2000 provides intense, long-lasting hydration, and Polynucleotides focus on biological repair and regeneration. Your practitioner will recommend the best option based on your skin's specific needs and goals.
Contact us to discuss which skin booster treatment is right for you and schedule your consultation.
Book Your Consultation