Skin TreatmentsMarch 2026Fulham, London

Are Polynucleotides Better Than Botox?
The Natural Alternative Explained (Results, Science & Timeline)

Polynucleotides are quickly being called the "natural alternative to Botox" By but do they live up to the hype? Here's the science, the results timeline, and how to decide which is right for you.

Polynucleotides are quickly being called the "natural alternative to Botox"By but are they actually better?

The truth is:

Polynucleotides and Botox do completely different things.

But for many people, polynucleotides can deliver healthier, more natural-looking results over time.

If you're deciding between the two, this guide explains everything:

  • what polynucleotides actually do to your skin
  • how they compare to Botox
  • how long results take and last
  • who they're best for

Not Sure Which Treatment Is Right for You?

Use our AI treatment finder to get personalised recommendations based on your skin concerns.

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What Are Polynucleotides?

Polynucleotides are fragments of DNA molecules, typically derived from purified salmon DNA, used to regenerate and repair the skin.

Unlike fillers or Botox, they don't add volume or freeze muscles.

Instead, they stimulate your skin to repair itself

They work by:

  • boosting collagen production
  • improving hydration
  • repairing damaged tissue
  • strengthening skin quality

Is This the "Salmon Sperm Facial"? (What That Actually Means)

You may have seen polynucleotides referred to as the:

"salmon sperm facial"

This term has gone viral online, but it's a simplified version of the science.

Polynucleotides are derived from highly purified DNA fragments, often sourced from salmon.

However:

  • they are not raw or unprocessed
  • they are refined into medical-grade injectable treatments
  • they are fully sterilised and clinically safe

Why Salmon DNA Is Used

Salmon DNA is particularly effective because:

  • it is highly compatible with human skin
  • it supports cellular regeneration
  • it improves hydration and repair

Why the Name Is Misleading

The phrase "salmon sperm facial" is:

  • designed to grab attention
  • not medically accurate
  • often misunderstood

In reality, this is a regenerative, science-led treatment

What Do Polynucleotides Actually Do to Your Skin? (Science Explained)

Polynucleotides work at a cellular level.

1. DNA-Level Repair

They provide building blocks that support tissue regeneration and healing.

2. Fibroblast Stimulation

Fibroblasts produce collagen and elastin.

Polynucleotides activate these cells, improving firmness and elasticity over time

3. Deep Hydration

They attract water into the skin, improving:

  • texture
  • glow
  • elasticity

4. Anti-Inflammatory Effects

They calm the skin, making them ideal for:

  • under eyes
  • sensitive skin
  • damaged skin

Polynucleotide Results: Before & After

Polynucleotide treatment before and after - facial skin improvement

Facial skin improvement with polynucleotide treatment

Polynucleotide treatment before and after - neck skin tightening

Neck skin tightening with polynucleotide treatment

What Does Botox Actually Do?

Botox works very differently.

It temporarily blocks nerve signals to muscles

This reduces movement and smooths:

  • forehead lines
  • frown lines
  • crow's feet

Why Botox Can Be Problematic Long-Term

Botox is effective, but it has limitations:

  • does not improve skin quality
  • requires repeated treatments
  • can weaken muscles over time
  • may create a less natural look if overused

It treats movement, not skin health

Polynucleotides vs Botox: What's the Difference?

BotoxPolynucleotides
Freezes musclesRepairs skin
Reduces wrinklesImproves skin quality
Instant resultsGradual results
TemporaryBuilds over time
Can look unnaturalNatural finish

Are Polynucleotides Better Than Botox?

It depends on your goal.

Choose Botox if:

  • you want quick wrinkle reduction
  • you're targeting deep lines

Choose Polynucleotides if:

  • you want healthier skin
  • you prefer natural results
  • you want long-term improvement

Many clients now combine both treatments for optimal results

Considering Polynucleotides?

Get personalised advice from our skin specialists to find the right treatment for your goals.

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How Long Do Polynucleotides Take to Work? (Results Timeline)

Week 1–2:

  • subtle hydration
  • fresher skin

Week 3–4:

  • improved texture
  • slight tightening

Week 6–12: PEAK RESULTS

  • smoother skin
  • better elasticity
  • brighter appearance

How Long Do Polynucleotides Last?

  • typically 4–6 months
  • longer with maintenance

How Many Sessions Do You Need?

2–3 sessions spaced 2–4 weeks apart

Then:

maintenance every 4–6 months

Who Are Polynucleotides Best For?

They are ideal if you:

  • want natural anti-ageing
  • have tired or dull skin
  • are concerned about under-eyes
  • want better skin quality

Are Polynucleotides Worth It?

For the right person:

yes, especially if your goal is long-term skin health

When Should You Have Polynucleotides? (Important Timing)

If you're planning a holiday or event, timing matters.

Read more here:

Pre-Holiday Beauty Prep Guide

FAQs

Are polynucleotides better than Botox?

They're different, polynucleotides improve skin, Botox reduces movement.

Do polynucleotides replace Botox?

No, but they can reduce the need for it.

Are polynucleotides safe?

Yes, when performed correctly by a trained practitioner.

How long do results take?

Results build gradually over weeks, with peak results at 6-12 weeks.

Not sure which treatment is right for you?

Describe your skin concerns and our treatment assistant will suggest suitable treatments. You can also message us on WhatsApp for personalised advice.

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Not Sure Which Treatment Is Right for Your Skin?

Use our AI treatment finder for personalised recommendations, or chat with us directly for expert advice.

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